Technology

Full bi-directional DNA sequencing is the most sensitive and accurate method of analyzing DNA. This methodology utilizes sophisticated automated devices to examine each element of a section of DNA. DNA is composed of a series of "bases" that are arranged in a particular order. Alterations in the specified order can cause disease. In the case of ADPKD, the alterations that cause the disease are in either of two genes, PKD1 and PKD2.

Now, in a major enhancement to the testing methodology, PKDx utilizes bi-directional sequencing to determine the precise order of the bases of a person's PKD1 and PKD2 genes. Although the technology is very complex, it is performed on a routine blood sample from an individual. The information it provides can be used by a physician to help understand more clearly the cause and prognosis of an individual's disease. It can also be used by the individual for planning purposes.